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white arrow indicates normal neuron) and hippokampal region CA1, right (control (HC), more neurons damage (black arrow indicates ballonized neuron, white arrow indicates normal neuron)

In IL-1-stimulated OA models, they upregulate SOX9 and COMP while suppressing ADAMTS4 activity, and micro-CT analysis shows 35% less subchondral bone loss

Upon activation, the NMDA receptor ion channel is no longer blocked by the voltage-dependent pore blocker Mg 2+ , allowing for the influx of Ca 2+ and Na + cations into the postsynaptic neuron [38]

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New insights into purine metabolism in metabolic diseases: role of xanthine oxidoreductase activity